Discovery Portfolio Manager
About us
Aerska is active in biotechnology, pioneering RNA medicines to treat, delay, and prevent diseases of the brain. We leverage advances in ‘brain shuttles’ to enable targeted delivery of next-generation RNAi therapeutics to the CNS. By silencing the genes that cause harm, Aerska aims to preserve minds, protect memories, and enable our loved ones to live longer, healthier lives.
Job description
As a discovery portfolio manager, you will drive the portfolio focus, discovery operations, and execution across a rapidly evolving pipeline of programs and platform capabilities. This is a high-impact, hands-on role operating across preclinical discovery, strategy, and execution, ensuring our programs progress efficiently from discovery to high-value assets.
- Continuously help to prioritize programs across AOCs, drug delivery strategies, and platform innovations
- Help define what work is best performed internally vs externally
- Manage and coordinate CRO operational activities across the discovery portfolio in collaboration with discovery program leads and matrix teams
- Work with scientific preclinical project leaders to ensure externally generated data is high quality, timely, and aligned with program decision needs
- Prevent 'black box' outsourcing by maintaining scientific and operational visibility
- Establish lightweight systems for portfolio tracking and experiment-to-decision alignment
- Facilitate discovery project teams in best practices around planning experiments and storing data, tracking project progress against agreed deliverables, and making effective data-driven decisions
- Ensure consistency in how data is generated, evaluated, and used across programs
Relevant work experience
- 5–10+ years in biotech/pharma, with exposure to antibody therapeutics, oligonucleotides, or conjugates
- early discovery and preclinical development
- Managing complex R&D programs in fast-paced environments
- Working across internal teams and external partners/CROs
- Experience with multi-disciplinary or platform-based programs
- Comfortable operating in high ambiguity, low structure environments
Skills required for the job